Cell Cycle: FBXW7.
|Human Gastric Cancer Copy Number PCR Array|
|The Human Gastric Cancer qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human stomach tumor DNA. Gastric cancer, or stomach cancer, originates in any part of the stomach, but can spread to other organs such as the esophagus, liver, lungs, and lymph nodes. Improving the very poor prognosis of this disease requires identifying early molecular markers, and progress has been made in identifying acquired copy number alterations (CNA) in key oncogenic pathways. During oncogenesis, large percentages of gastric tumors acquire insertions and deletions in genes that regulate epithelial cell and fibroblast proliferation and differentiation, as well as signaling pathways such as WNT. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and gastric cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify gastric cancer samples by genotype and help verify gastric cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.|
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.
Channels & Transporters: ATP7B.
Chaperone Activity: BAG2.
Cytoskeleton: CTNNB1, FAM84B, IQGAP1.
ECM & Cell Adhesion: ADAM23, CD44, CEACAM6.
G-Protein Signaling: DOCK8, IQGAP1.
Growth Factors: SFRP1, WNT2.
Hedgehog Signaling: MTSS1, RAB23.
Metabolic Enzymes: AOAH, GLO1, MTAP.
Receptor Tyrosine Kinases: ERBB3.
Transcription Factors: FOXO1, ZFHX3.
Ubiquitin Ligase: FBXW7.
Others: LRRC4C, PPP1R1B.