科技服务 > PCR芯片实验服务 > 真人投注平台PCR芯片 Inflammasomes PCR Array

真人投注平台PCR芯片 Inflammasomes PCR Array

真人投注平台PCR芯片 Inflammasomes PCR Array
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简介:Inflammasomes PCR Array真人投注平台PCR芯片
提供商:SAbiosciences
服务名称:真人投注平台PCR芯片
地区:美国
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Inflammasomes PCR Array

真人投注平台PCR芯片
 
ProductSpeciesTechnologyCat. No.
Inflammasomes PCR ArrayHumanGene ExpressionPAHS-097Z
Inflammasomes PCR ArrayMouseGene ExpressionPAMM-097Z
Inflammasomes PCR ArrayRatGene ExpressionPARN-097Z
The Human Inflammasomes RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in the function of inflammasomes, protein complexes involved in innate immunity, as well as general NOD-like receptor (NLR) signaling. NLRs represent a major class of cytosolic pattern recognition receptors (PRR) that, like their cell-surface Toll-Like Receptor counterparts, recognize a wide variety of microbial pathogens and immunogenic biological products. Activation of one of four PRR family members (AIM2, NLRC4 or IPAF, NLRP1, and NLRP3) initiates the formation of an inflammasome. These protein complexes in turn activate caspase-1, leading to up-regulation of the pro-inflammatory cytokines IL1B and IL18 and pyroptosis, or caspase-1-dependent programmed cell death. This array includes genes encoding inflammasome components as well as genes involved in downstream signaling and inhibition of inflammasome function. In addition, this array includes other NLR family members, which may potentially form additional inflammasomes, and their downstream signaling genes. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes involved in inflammasome and NLR function and signaling with this array.
真人投注平台PCR芯片检测84个关键基因的表达,包括真人投注平台体相关基因,先天免疫的蛋白复合物,以及一般的NOD样受体(NLR)信号基因。NLRs是一类主要的胞浆内模式识别受体(PRR),与细胞表面Toll样受体一样,识别多种多样的病原微生物和免疫原性生物产物。PRR四个家庭成员(AIM2、NLRC4/IPAF、NLRP1和NLRP3)中任何一个的激活,都将引起真人投注平台体的形成。而这些蛋白质复合物又反向激活caspase-1,使促真人投注平台细胞因子IL1B、IL18和pyroptosis上调,从而导致炎症坏死,以及caspase-1依赖的程序性细胞死亡。芯片包括编码真人投注平台体组件的基因、真人投注平台体功能发挥的下游信号和抑制基因、其他NLR家庭成员,以及可能形成更多的真人投注平台体和其下游信号的基因。通过实时定量PCR的方法,研究者即能够利用该芯片简单可靠地同时检测真人投注平台体和NLR功能和信号相关的基因表达.
Inflammasomes:
AIM2: AIM2, CASP1 (ICE), PYCARD (ASC).
IPAF: CASP1, NAIP, NLRC4 (IPAF), PYCARD (ASC).
NLRP1: CASP1 (ICE), CASP5, NLRP1.
NLRP3: CASP1 (ICE), NLRP3, PYCARD (ASC).
Negative Regulation: BCL2, BCL2L1 (BCL-X), CARD18 (ICEBERG), CD40LG (TNFSF5), CTSB, HSP90AA1, HSP90AB1, HSP90B1 (TRA1), MEFV, PSTPIP1, PYDC1 (POP1), SUGT1, TNF, TNFSF11, TNFSF14, TNFSF4 (OX40L).
Downstream Signaling: IFNG, IL12A, IL12B, IL18, IL1B, IL33, IRAK1, IRF1, MYD88, P2RX7, PANX1, PTGS2 (COX2), MOK, RIPK2, TIRAP, TXNIP.
NOD-Like Receptors:
Receptors: CIITA, NAIP (BIRC1), NLRC4 (IPAF), NLRC5, NLRP1, NLRP12, NLRP3, NLRP4, NLRP5, NLRP6, NLRP9, NLRX1, NOD1 (CARD4), NOD2.
Downstream Signaling: BIRC2 (c-IAP2), BIRC3 (c-IAP1), CARD6, CASP8 (FLICE), CCL2 (MCP-1), CCL5 (RANTES), CCL7 (MCP-3), CFLAR (CASPER), CHUK (IKKa), CXCL1, CXCL2, FADD, IFNB1, IKBKB, IKBKG, IL6, IRF1, IRF2, MAP3K7 (TAK1), MAPK1 (ERK2), MAPK11, MAPK12, MAPK13, MAPK3 (ERK1), MAPK8 (JNK1), MAPK9 (JNK2), NFKB1, NFKBIA (I?Ba/MAD3), NFKBIB (TRIP9), PEA15, RELA, RIPK2, SUGT1, TAB1 (MAP3K7IP1), TAB2 (MAP3K7IP2), TNF, TRAF6, XIAP.
Pro-Inflammatory Caspases: CASP1 (ICE), CASP5


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