|Human WNT Signaling Pathway Copy Number PCR Array|
|The Human WNT Signaling Pathway qBiomarker Copy Number PCR Array profiles the copy number of 23 WNT signaling-related genes reported to undergo frequent genomic alterations. Genes selected include WNT pathway components, molecules/pathways that cross-talk with the WNT pathway, and WNT pathway effectors. These genes encode cell adhesion molecules, receptors, transcription factors and other signaling proteins that regulate processes such as the cell cycle, migration, cancer, and cellular differentiation, as well as developmental disorders. DNA copy number changes in WNT-related genes have been reported in multiple cancers. Genes were chosen from the most frequently amplified or deleted genes relevant to WNT signaling based on the primary literature and public databases. This array may serve as a useful tool to help classify samples by genotype and help verify phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.|
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.
Cell Adhesion: CDH1, CDH13.
Cell Cycle: CCND1.
Cytoskeleton Regulators: GRB7, MARK4.
Growth Factor & Hormone Receptors: AR, ERBB2, FGFR2.
Intracellular Signaling Molecules: APC, DVL1, NKD2, PTK6.
MicroRNA Genes: MIR17HG, MIR517C.
Positive Regulator of WNT Signaling: C8orf4.
Transcription Factors: AR, FOSL1, IRX2, JUN, MYC, MYCN, PLAGL2, TP53.
WNT Target Genes: CCND1, CDH1, FOSL1, JUN, MYC.