科技服务 > PCR芯片实验服务 > 视黄酸信号通路PCR芯片 Retinoic Acid Signaling PCR Array

视黄酸信号通路PCR芯片 Retinoic Acid Signaling PCR Array

视黄酸信号通路PCR芯片 Retinoic Acid Signaling PCR Array
运费 ¥0.00
(库存 9999 件)
简介:Retinoic Acid Signaling PCR Array
提供商:qiagen
服务名称:PCR芯片
地区:上海
The Human Retinoic Acid Pathway RT² Profiler PCR Array profiles the expression of 84 key genes involved in retinoic acid signaling. Retinoic acid (RA) is the primary functional derivative of vitamin A (retinol) and its activity is implicated in many aspects of vertebrate development and homeostasis, while disruptions in this pathway cause developmental abnormalities and disrupt function in adipose, cardiac, nervous, reproductive, and integumentary tissues, among others. RA acts primarily by binding a family of nuclear receptors (the retinoic acid receptors alpha, beta, and gamma) that then heterodimerize with their partners (the retinoid X receptors alpha, beta, and gamma) and alter transcription. Additionally, recent evidence suggests that an alternative receptor (PPAR delta) also responds to RA signaling in some tissues and that retinol, and RA may also induce non-genomic cellular effects. Thus, the effect of RA depends on the expression of its cognate receptors, enzymes responsible for converting retinol to RA, metabolic enzymes that reduce RA levels, and transport proteins, some of which act as signal transducers that appear to influence the distribution of RA and its metabolic precursors. This array includes genes encoding the known receptors and proteins responsible for synthesis, transport and metabolism of RA and its precursors, as well as downstream targets of RA signaling. Results obtained with this array can yield insights into RA signaling mechanisms and responses. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification and assessment of reverse transcription performance, genomic DNA contamination, and PCR performance. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in retinoic acid signaling with this array.

The RT² Profiler PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.

 

96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.
Available for cells, tissues, FFPE samples and small samples


姓名
电话号码
电子邮箱
公司名称
地址
留言*
 
验证码
提交
我是混淆代码

如果您的浏览器未跳转,请点击此处进行游戏并领取优惠

技术支持 AI智能站群 luis888.vip@gmail.com