AKT / PI-3-Kinase Signaling: AKT1, AKT2, AKT3, PIK3CA.
|Human Kinases & Phosphatases Copy Number PCR Array|
|The Human Kinases & Phosphatases qBiomarker Copy Number PCR Array profiles the copy number of 23 genes encoding kinases or phosphatases reported to undergo frequent genomic alterations. DNA copy number changes in kinases and phosphatases occur frequently in cancer. The genes on the array encode both key kinases and phosphatases that regulate processes such as the cell cycle, insulin and other hormone receptor signaling, PI-3-K signaling, apoptosis, cell migration, and motility. Genes were chosen from the most frequently amplified or deleted kinase and phosphatase genes based on the primary literature and public databases. This array may serve as a useful tool to help classify samples by genotype and help verify phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.|
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.
Cyclin-Dependent Kinase: CDK4.
Cytoskeleton: AURKA, PTK2, STK11.
MAP Kinase Signaling: MAP2K4.
Metabolism: FHIT, PDK1.
Receptor Tyrosine Kinases & Signaling: ALK, EGFR, ERBB2, FGFR2, IGF1R, MET, PDGFRA, SIK2.
Ribosomal Protein Kinase: RPS6KB1.
Phosphatases: FHIT, PPAPDC1B, PTEN, PTPRD.