Development & Differentiation: HCK, MAFB, MEN1, TP53.
|Human Leukemia & Lymphoma DNA Methylation PCR Array, Signature Panel:|
|The Human Leukemia & Lymphoma EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 tumor suppressor gene promoters whose hypermethylation has been reported in the literature to occur frequently in a variety of leukemia and lymphomas. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also provide insights into the molecular mechanisms and biological pathways behind oncogenesis and cancer pathology. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different leukemia and lymphoma genes with this DNA methylation PCR array.|
Both 96-well and 384-well ( 4 X 96 ) formats are available.
The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC.
Cell Cycle: JUNB, MEN1, NPM1, TP53.
DNA Damage & Repair: FANCC, FANCL, NPM1, TP53.
Extracellular Matrix & Adhesion: CD9, CTNNA1, SPOCK2.
Growth & Proliferation: DRD2, MEN1, NPM1, SLC5A8, TP53.
Signal Transduction: DRD2, EXT1, MEN1, NFATC1, NPM1, PER2, TLE1, TP53.
Transcription Factors & Co-Factors: AFF1, CEBPD, HOXA7, HOXB5, JUNB, MAFB, NFATC1, NPM1, TLE1, TP53.