Non-Small Cell Lung Cancers (NSCLC): CCND1, CDKN2A, CSMD1, EGFR, KRAS, MET, MYC, PIK3CA.
|Human Lung Cancer Copy Number PCR Array|
|The Human Lung Cancer qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human lung tumor DNA. Recent studies have uncovered gene copy number alterations as a major mechanism that contributes to disease initiation and progression. The genes on the array encode transcription factors, receptors, and growth factors that regulate processes such as the cell cycle and DNA damage repair. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and lung cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify lung cancer samples by genotype and help verify lung cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.|
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.
Lapatinib Sensitivity: CDKN2A.
AKT & PI-3-Kinase Signaling: AKT1, PIK3CA, PTEN.
Cell Adhesion & Cytoskeleton: CSMD1, CTNND1.
Cell Cycle: CCND1, CDKN2A, MDM2.
Growth Factors: VEGFA.
RAS Signaling: KRAS.
Transcription Factors: MYC, NKX2-1, NKX2-8, RB1, SKIL, SOX2, TFDP1.
Tyrosine Kinase Receptors: EGFR, IGF1R, KIT, MET, PDGFRA, RB1.